SOX11

SOX11
المعهدات
الأسماء المستعارة	SOX11, MRD27, SRY-box 11, CSS9, SRY-box transcription factor 11
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600898 MGI: MGI:98359 HomoloGene: 37733 GeneCards: 6664
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إذا إي; • ‏GO:0001105 transcription coactivator activity; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • ‏GO:0001077، ‏GO:0001212، ‏GO:0001213، ‏GO:0001211، ‏GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • translation factor activity, RNA binding; • transcription regulatory region sequence-specific DNA binding; • ‏GO:0001158 core promoter proximal region sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
المكونات الخلوية	• سيتوبلازم; • نواة;
العمليات الحيوية	• تشكل الهيكل العظمي الجنيني; • skeletal system development; • noradrenergic neuron differentiation; • positive regulation of lens epithelial cell proliferation; • تمايز خلوي; • cardiac ventricle formation; • glial cell development; • ضبط نسخ الدنا; • limb bud formation; • lung morphogenesis; • sympathetic nervous system development; • neural crest cell development; • تطور الكلى; • negative regulation of glial cell proliferation; • signal transduction involved in cell cycle checkpoint; • soft palate development; • ventricular septum morphogenesis; • cornea development in camera-type eye; • outflow tract morphogenesis; • positive regulation of ossification; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of cell death; • transcription from RNA polymerase II promoter; • eyelid development in camera-type eye; • negative regulation of gene expression; • negative regulation of lymphocyte proliferation; • somite development; • نسخ الدنا; • neuroepithelial cell differentiation; • regulation of transforming growth factor beta receptor signaling pathway; • nervous system development; • positive regulation of transcription, DNA-templated; • positive regulation of hippo signaling; • positive regulation of neurogenesis; • نمومتعدد الخلايا; • positive regulation of gene expression; • positive regulation of osteoblast differentiation; • lens morphogenesis in camera-type eye; • negative regulation of transcription regulatory region DNA binding; • hard palate development; • positive regulation of neuron differentiation; • neuron differentiation; • ضبط زيادي للتكاثر الخلوي; • spinal cord development; • positive regulation of BMP signaling pathway; • glial cell proliferation; • skeletal muscle cell differentiation; • embryonic digestive tract morphogenesis; • oligodendrocyte development; • cellular proliferation; • positive regulation of stem cell proliferation; • neural tube formation; • positive regulation of hormone secretion; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • closure of optic fissure; • اصطناع حيوي للبروتين;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P35716
	Q7M6Y2
	NM_003108
	NM_009234
	NP_003099
	NP_033260
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

SOX11‏ (SRY-box 11) هوَ بروتين يُشَفر بواسطة جين SOX11 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Sep 1995). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics. 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
^ "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry. 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.

قراءة متعمقة

Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Gozé C, Poulat F, Berta P (Jun 1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Research. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (Jun 1998). "Cooperative function of POU proteins and SOX proteins in glial cells". The Journal of Biological Chemistry. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M (Oct 1999). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Research. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.
Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ (May 2002). "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM (Jul 2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development. 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.
Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F (Nov 2005). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". The Journal of Biological Chemistry. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.
DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research. 112 (1–2): 176–9. doi:10.1159/000087532. PMID 16276109.