BHLHB2

BHLHE40
المعهدات
الأسماء المستعارة	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604256 MGI: MGI:1097714 HomoloGene: 2722 GeneCards: 8553
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إذا إي; • protein dimerization activity; • protein homodimerization activity; • MRF binding; • ‏GO:0001106 transcription corepressor activity; • protein domain specific binding; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • RNA polymerase II activating transcription factor binding; • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • bHLH transcription factor binding; • E-box binding; • ‏GO:0001948 ربط بروتيني; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II regulatory region sequence-specific DNA binding; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • transcription factor binding; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
المكونات الخلوية	• سيتوبلازم; • نواة; • نقاط نووية;
العمليات الحيوية	• ضبط نسخ الدنا; • response to light stimulus; • rhythmic process; • negative regulation of transcription from RNA polymerase II promoter; • circadian regulation of gene expression; • نسخ الدنا; • negative regulation of sequence-specific DNA binding transcription factor activity; • negative regulation of transcription, DNA-templated; • entrainment of circadian clock by photoperiod; • نظم يوماوي; • تكون الجسيدات; • Notch signaling pathway; • تمايز خلوي; • regulation of neurogenesis;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O14503
	O35185
	‏XM_024453798 NM_003670، ‏XM_024453798
	NM_011498
	‏XP_024309566 NP_003661، ‏XP_024309566
	NP_035628
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

BHLHB2‏ (Basic helix-loop-helix family member e40) هوَ بروتين يُشَفر بواسطة جين BHLHB2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Antonevich T, Taneja R (Oct 1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 254–5. doi:10.1159/000015305. PMID 10449910.
^ Stevens JD, Roalson EH, Skinner MK (Nov 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763.
^ Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y (Jul 1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochemical and Biophysical Research Communications. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428.

قراءة متعمقة

Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y (Mar 2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". Journal of Biochemistry. 129 (3): 391–6. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.
Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (May 2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694.
Sun H, Lu B, Li RQ, Flavell RA, Taneja R (Nov 2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nature Immunology. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339.
Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O (Nov 2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochemical and Biophysical Research Communications. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991.
Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B (Oct 2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". The Biochemical Journal. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049.
St-Pierre B, Flock G, Zacksenhaus E, Egan SE (Nov 2002). "Stra13 homodimers repress transcription through class B E-box elements". The Journal of Biological Chemistry. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495.
Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y (Dec 2002). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". The Journal of Biological Chemistry. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771.
Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y (Dec 2002). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". The Journal of Biological Chemistry. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505.
Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K (Oct 2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359.
Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (May 2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". The Journal of Biological Chemistry. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110.
Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL (Jun 2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". The Journal of Pathology. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744.
Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI (Jul 2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y (Nov 2004). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". European Journal of Biochemistry / FEBS. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
Ivanova AV, Ivanov SV, Lerman ML (Feb 2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cellular and Molecular Life Sciences. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173.
Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ (Jul 2005). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". Journal of Medical Genetics. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.