SLITRK1

SLITRK1
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4RCA, 4RCW
المعهدات
الأسماء المستعارة	SLITRK1, LRRC12, TTM, SLIT and NTRK like family member 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 609678 MGI: MGI:2679446 HomoloGene: 14174 GeneCards: 114798
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني;
المكونات الخلوية	• مكون تكاملي للغشاء; • غشاء; • تشابك عصبي; • منطقة خارج الخلية; • موصل خلوي; • غشاء خلوي; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic density membrane;
العمليات الحيوية	• adult behavior; • nervous system development; • multicellular organism growth; • homeostatic process; • positive regulation of synapse assembly; • synapse assembly; • positive regulation of axonogenesis; • axonogenesis; • regulation of synapse organization; • synaptic membrane adhesion; • regulation of presynapse assembly;
	المصادر:Amigo / QuickGO
أورثولوج
	Q96PX8
	Q810C1
	‏NM_001281503 NM_052910، ‏NM_001281503
	NM_199065
	‏NP_443142 NP_001268432، ‏NP_443142
	NP_951020
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

SLITRK1‏ (SLIT and NTRK like family member 1) هوَ بروتين يُشَفر بواسطة جين SLITRK1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Aruga J, Yokota N, Mikoshiba K (Oct 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
^ "Entrez Gene: SLITRK1 SLIT and NTRK-like family, member 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

قراءة متعمقة

Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Aruga J, Mikoshiba K (2004). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Mol. Cell. Neurosci. 24 (1): 117–29. doi:10.1016/S1044-7431(03)00129-5. PMID 14550773.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Abelson JF, Kwan KY, O'Roak BJ, et al. (2005). "Sequence variants in SLITRK1 are associated with Tourette's syndrome". Science. 310 (5746): 317–20. doi:10.1126/science.1116502. PMID 16224024.
Burton A (2006). "SLITRK1 trouble in Tourette's syndrome". Lancet Neurology. 4 (12): 801. doi:10.1016/S1474-4422(05)70242-8. PMID 16323357.
Wendland JR, Kruse MR, Murphy DL (2006). "Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder". Mol. Psychiatry. 11 (9): 802–4. doi:10.1038/sj.mp.4001848. PMID 16936762.
Zuchner S, Cuccaro ML, Tran-Viet KN, et al. (2006). "SLITRK1 mutations in trichotillomania". Mol. Psychiatry. 11 (10): 887–9. doi:10.1038/sj.mp.4001865. PMID 17003809.