سمية الخلية المعتمدة على الأجسام المضادة بوساطة الخلية

سمية الخلية المعتمدة على الأجسام المضادة.

الأجسام المضادة (antibody-dependent cell-mediated cytotoxicity ‏ADCC)، ويشار إليها أيضاً بإسم antibody-dependent cellular cytotoxicity، هي آلية cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies. It is one of the mechanisms through which antibodies, as part of the humoral immune response, can act to limit and contain infection.

ADCC is independent of the immune complement system that also lyses targets but does not require any other cell. ADCC requires an effector cell which classically is known to be natural killer (NK) cells that typically interact with IgG antibodies. However, macrophages, neutrophils and eosinophils can also mediate ADCC, such as eosinophils killing certain parasitic worms known as helminths via IgE antibodies.

ADCC is part of the adaptive immune response due to its dependence on a prior antibody response. The coating of target cells with antibodies is sometimes referred to as opsonization.

انظر أيضاً

Afucosylated monoclonal antibodies

الهامش

^ Hashimoto, G.; Wright, P. F.; Karzon, D. T. (1983-11-01). "Antibody-dependent cell-mediated cytotoxicity against influenza virus-infected cells". The Journal of Infectious Diseases. 148 (5): 785–794. doi:10.1093/infdis/148.5.785. ISSN 0022-1899. PMID 6605395.
^ Pollara, Justin; Hart, Lydia; Brewer, Faraha; Pickeral, Joy; Packard, Beverly Z.; Hoxie, James A.; Komoriya, Akira; Ochsenbauer, Christina; Kappes, John C. (2011-08-01). "High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses". Cytometry Part A. 79 (8): 603–612. doi:10.1002/cyto.a.21084. ISSN 1552-4930. PMC 3692008. PMID 21735545.
^ Wang, W; Erbe, AK; Hank, JA; Morris, ZS; Sondel, PM (2015). "NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy". Front Immunol. 6: 368. doi:10.3389/fimmu.2015.00368. PMC 4515552. PMID 26284063.
^ Capron, M; Kazatchkine, MD; Fischer, E; Joseph, M; Butterworth, AE; et al. (1987). "Functional role of the alpha-chain of complement receptor type ثلاثة in human eosinophil-dependent antibody-mediated cytotoxicity against schistosomes". J Immunol. 139 (6): 2059–65. PMID 2957447.

للاستزادة

Janeway CA Jr.; et al. (2001). Immunobiology (5th ed.). Garland Publishing. ISBN . (electronic full text via NCBI Bookshelf).
Pier GB, Lyczak JB, Wetzler LM (2004). Immunology, Infection, and Immunity. ASM Press. ISBN .