LRP6

LRP6
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7
المعهدات
الأسماء المستعارة	LRP6, ADCAD2, STHAG7, LDL receptor related protein 6
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 603507 MGI: MGI:1298218 HomoloGene: 1747 GeneCards: 4040
فهم الوجود الجيني
الوظيفة الجزيئية	• low-density lipoprotein receptor activity; • apolipoprotein binding; • protein homodimerization activity; • kinase inhibitor activity; • ‏GO:0005110 frizzled binding; • Wnt-protein binding; • toxin transporter activity; • ‏GO:0001948 ربط بروتيني; • coreceptor activity involved in Wnt signaling pathway; • identical protein binding; • Wnt-activated receptor activity; • receptor binding; • coreceptor activity involved in canonical Wnt signaling pathway;
المكونات الخلوية	• مكون تكاملي للغشاء; • Wnt-Frizzled-LRP5/6 complex; • Wnt signalosome; • جهاز غولجي; • early endosome membrane; • غشاء; • receptor complex; • تشابك عصبي; • منطقة خارج الخلية; • cell surface; • neuronal cell body; • early endosome; • شبكة إندوبلازمية; • غطاء الحويصلة; • حويصلة سيتوبلازمية; • غشاء خلوي; • membrane raft;
العمليات الحيوية	• negative regulation of protein phosphorylation; • Wnt signaling pathway involved in somitogenesis; • cerebellum morphogenesis; • palate development; • dopaminergic neuron differentiation; • positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; • ضبط نسخ الدنا; • إدخال خلوي; • receptor-mediated endocytosis involved in cholesterol transport; • embryonic pattern specification; • convergent extension; • negative regulation of protein kinase activity; • thalamus development; • axis elongation involved in somitogenesis; • canonical Wnt signaling pathway involved in neural crest cell differentiation; • positive regulation of cytosolic calcium ion concentration; • response to peptide hormone; • canonical Wnt signaling pathway involved in regulation of cell proliferation; • neural crest cell differentiation; • positive regulation of sequence-specific DNA binding transcription factor activity; • Wnt signaling pathway; • cellular response to cholesterol; • neural crest formation; • trachea cartilage morphogenesis; • positive regulation of transcription, DNA-templated; • odontogenesis of dentin-containing tooth; • نمومتعدد الخلايا; • midbrain-hindbrain boundary development; • neural tube closure; • positive regulation of cell cycle; • external genitalia morphogenesis; • Wnt signaling pathway involved in dorsal/ventral axis specification; • pericardium morphogenesis; • cerebral cortex development; • embryonic retina morphogenesis in camera-type eye; • canonical Wnt signaling pathway; • negative regulation of protein serine/threonine kinase activity; • protein localization to plasma membrane; • negative regulation of canonical Wnt signaling pathway; • negative regulation of smooth muscle cell apoptotic process; • face morphogenesis; • primitive streak formation; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • chemical synaptic transmission; • toxin transport; • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • positive regulation of canonical Wnt signaling pathway; • beta-catenin destruction complex disassembly; • midbrain dopaminergic neuron differentiation; • gastrulation with mouth forming second; • نقل شاردة الكالسيوم; • embryonic limb morphogenesis; • midbrain development; • تجدد العظام; • embryonic camera-type eye morphogenesis; • bone morphogenesis; • branching involved in mammary gland duct morphogenesis; • cell-cell adhesion;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O75581
	O88572
	‏XM_006719078، ‏XM_011520671، ‏XR_429035، ‏XR_002957325 NM_002336، ‏XM_006719078، ‏XM_011520671، ‏XR_429035، ‏XR_002957325
	‏XM_006505657 NM_008514، ‏XM_006505657
	‏XP_006719141، ‏XP_011518973 NP_002327، ‏XP_006719141، ‏XP_011518973
	‏XP_006505720 NP_032540، ‏XP_006505720
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

LRP6‏ (LDL receptor related protein 6) هوَ بروتين يُشَفر بواسطة جين LRP6 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021.

قراءة متعمقة

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